01/2023 New paper out! Great collaboration with the psychiatry/neuroimaging team of Marseille! Global and local cortical folding alterations are associated with neurodevelopmental subtype in bipolar disorders: a sulcal pits analysis. Check it out: Lefrere et al., 2023
06/2022 I'm very happy to share that I received a grant from the French National Research Agency (ANR) to study the "Bayesian Bipolar Brain at 7T"! More info here: ANR link. PhD and Post-doc applications are welcome! :)
07/2022 New paper out! Real-time fMRI neurofeedback as a new treatment for psychiatric disorders? A meta analysis. Check it out: Pindi et al., 2022
10/2021 I am delighted to share that I have been recruited as tenured researcher (chargée de recherche) at INSERM: https://www.imrb.inserm.fr/actualites/felicitations-a-pauline-favre-nouvellement-recrutee-en-qualite-de-chargee-de-recherche-a-linserm-au-sein-de-lequipe-de-marion-leboyer/
05/2021 Our fMRI paper on the effect of 3 different meditation trainings on emotion reactivity is out in Neuroimage. Check it out (open access): https://www.sciencedirect.com/science/article/pii/S1053811921004092
12/2019: I am very happy to have won the second prize for the best paper of the year at the French Congress of Psychiatry in Nice!
08/2019: Our ENIGMA paper on white matter abnormailities in bipolar disorder is out in Neuropsychopharmacology Click here to access to the full text. Check interactive results HERE.
10/2018: I am honored to receive the UNAFAM Research Award 2018. Check the video for more details.
10/2018 I am starting a new post-doc position at INSERM U955 in the translational psychiatry team.
My research focuses on understanding the cognitive and cerebral mechanisms underlying: (1) Emotion processing and regulation in the general population and in psychiatric disorders such as bipolar disorder and; (2) The positive effects of cognitive or mental trainings, such as psychosocial interventions and meditation-based mental training in these populations. I use a combination of cognitive paradigms as well as functional and anatomical MRI to pursue these objectives.
Bipolar Disorders; Brain Plasticity; Emotions; Cognitive training; MRI; fMRI
The Bipolar Bayesian Brain at 7T: Mood disturbances in bipolar disorder studied with ultra-high field MRI
Bipolar disorder (BD) is a chronic mood disorder characterized by emotional hyperresponsiveness during acute periods (i.e., mania and depression), as well as during periods of remission (i.e., euthymia). Current neurocognitive models suggest that lack of cognitive control may be responsible for these symptoms, but do not explain the recurrence of mood cycles in BD. The objective of this project is to clarify the cognitive mechanisms responsible for extreme mood variations in BD and to identify the underlying cerebral correlate. We assume that patients with BD would exhibit an early perceptual bias when processing emotions, that would also be congruent with their mood. On the one hand, regardless of their mood, patients would tend to "over-predict" emotions, leading to "top-down" prediction errors and abnormal connectivity between the amygdala, the orbito-frontal cortex, and the visual system. On the other hand, the valence of this expectation bias would depend on their mood state and would be underpinned by an imbalance of connectivity between the amygdala, the hippocampus, and the nucleus accumbens. We will use ultra-high field MRI (7 Tesla) which, thanks to a very high spatial resolution and a very high signal-to-noise ratio, will allow us to precisely measure the connectivity of these regions. We will employ a dimensional approach, including 60 patients in different mood states: euthymic, depressed, or hypomanic, as well as 30 healthy controls. We will use ecological momentary assessment (EMA) to characterize as precisely as possible the mood of the patients at the time of the MRI scan. From the theoretical perspective, this project will contribute to the modeling of the neurocognitive processes involved in the regulation of mood. From a clinical and societal perspective, it will help to improve the diagnosis of mood disorders and will open new perspectives for the treatment of patients with BD.
Real-time fMRI neurofeedback as treatment for inter-critical mood symptoms in bipolar disorder: a randomized controlled trial
This multicentrer national study aims at assessing the efficacy of 3-weeks neurofeedback training with real-time fMRI on the treatment of residual mood symptoms in patients with BD. I am leading this study with Pr. J. Houneou.
Check out my video presentation of the project during the french neurofeedback congress (Bordeaux, 2019) here (in French).
Check out my interview about the project here
In this multi-center international study, conducted under the umbrella of the ENIGMA consortium, I am working with DTI data from about 3000 subjects (half patients with bipolar disorder, half controls) from 26 cohorts, thus constituting the largest DTI database of bipolar patients known today. My goal is to identify reliably and reproducibly, with the use of machine learning algorythms, white matter microstructural abnormalities that could characterize these patients.
The ReSource project is a large-scale longitudinal study on meditation-based mental training. The goal of this 11-month program is to cultivate compassion, gratitude, motivation pro-social, etc. but also to improve subjective well-being and health through different mental training modules (3 months each). The “Presence” module focuses on attention training and interoceptive awareness. The "Affect" module aims to strengthen compassion and gratitude towards others as well as to improve the management of difficult emotions through the training of socio-emotional skills. The objective of the module "Perspective" is to train the socio-cognitive skills, such as theory of mind and metacognitive capacities.
The purpose of my work in this project are i) to evaluate change in emotional reactivity and its associated cerebral network after the overall ReSource program as well as the differential effect the 3 modules; ii) to evaluate change in mindwandering content after these training with an experience sampling paradigm.
Description: The BiPed project is my PhD project. The objectives of this project were, first, to identify brain abnormalities underlying emotional and cognitive disorders in bipolar disorders, and second, to identify how psychoeducation, a specific and structured psychosocial intervention, can modulate these brain abnormalities.
Publications : Favre et al., 2016, Psychotherapy and Psychosomatics; Favre et al., 2015, PloS One; Favre et al., 2014, JAD; Favre et al., 2013, Psych. Res.: Neuroimaging.
Description: This clinical study aims to evaluate the effectiveness of transcranial magnetic stimulation (TMS) in the treatment of obsessive-compulsive disorder (OCD). The originality of this study lies in the choice of the target region, which is determined individually by an fMRI task measuring motor impulsivity: the "Stop Signal Task" (SST).
Description: This project focuses on the effects of the mindfulness meditation FOVEA program on i) low-level emotional visual perception (by manipulating the spatial frequency of images) and ii) on eating behaviors, food impulsivity in particular.
Tenured researcher (chargée de recherche) at INSERM U955, team « Translational Neuro-Psychiatry » (Créteil, France)
Senior Post-doc at INSERM U955, team « Translational Neuro-Psychiatry » (Créteil, France)
Post-doctoral researcher at Neurospin research center (CEA – Paris Saclay)
Post-doctoral researcher at the Max Planck Institute for Human Cognition and Brain Science, Dept. of Social Neuroscience (Leipzig, Germany)
“In-Doc” Research internship in the University of Cambridge (UK)
PhD in Cognitive Sciences, Psychology and Neurocognition (Lab of Psychology and NeuroCognition, Grenoble, France)
Research Master (2nd yr): National master on Clinical Neurosciences and Neuropsychology (University of Grenoble, Lyon and Toulouse, France)
Master (1st yr) in Cognitive Psychology (University of Grenoble, France)
Bachelor in Psychology (University of Grenoble, France)
Baccalaureate in Science (Specialty: Biology), Academy of Grenoble
Link to download my PhD thesis
!!! Don’t hesitate to contact me if you’re looking for a Post-Doc, a PhD or an internship !!!
Team "PsyBrain" Neurospin / INSERM U955
Team "PsyBrain" Neurospin / INSERM U955
Max Planck Institute in Leipzig, Germany
University Grenoble Alpes, Grenoble, France
Lecturer in Psychology degree
Teacher assistant in Psychology degree